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Specifically, the tumor metabolite lactate regulates the stability and function of Treg cells through lactylating MOESIN at lysine 72, enhancing its interaction with TGF- receptor I and activating downstream SMAD3 signaling

Methods: We performed a systematic review of the literature using Medline, Embase and Cochrane databases from inception to February 2023 to identify studies evaluating the effect of metformin use in DM patients with compensated cirrhosis of any etiology on all-cause mortality or transplantation and liver disease decompensation

As GSH represent the primary antioxidant defense system, the reduction of GSH could influence the redox homeostasis and elevate the naturally occurring ROS levels inside the cancer cells 40

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Curr Opin Clin Nutr Metab Care 2014;17, 324-328, doi:10.1097/MCO.0000000000000065

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